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- DIM (3,3′-Diindolylmethane), which is abundant in cruciferous vegetables, like broccoli, cauliflower, and cabbage, has shown anti-tumor activity, inhibits cancer cell proliferation in estrogen receptor positive and negative cells, and has shifted urinary estrogen metabolites to those with lower cancer risk among cancer survivors.,,
- Suggested dose: DIM 250 mg per day.
- Vitamin D levels are associated with both the risk of breast cancer as well as the risk of dying from it.
- Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.
Pterostilbene & Resveratrol
- Found in red wine and grapes, this antioxidant has been shown to influence the methylation of genes in women at high breast cancer risk, and to reduce the toxicity of radiation therapy.,
- Suggested dose: 100-200 mg per day.
- This antioxidant has multiple mechanisms by which it inhibits breast cancer proliferation and induces apoptosis (programmed cell death), and alters the metabolism of estrogen to less toxic compounds., It may be particularly beneficial for Her2/neu positive cancer.
- Suggested dose: 200-400 mg, three times per day.