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Probiotic Reduces Fat Mass and Reduces Glucose Intolerance in Obese Mice

In a 12 week study involving mice, it was found that the probiotic, Bifidobacterium animalis ssp. lactis 420 (109 cfu) reduces fat mass and glucose intolerance in obese and diabetic mice. Mice were divided into two groups. In the obesity model, they were fed a high-fat diet for 12 weeks, and gavaged daily with B lactis 420 (109 cfu) or vehicle.

In the diabetes model, mice were fed a high-fat ketogenic diet for 4 weeks, with a 6-week subsequent treatment with B lactis 420 (108-110 cfu/d) or vehicle. Glucose intolerance and intestinal bacterial translocation and adhesion were analyzed as well. Body fat mass was increased in both obese and diabetic mice. Treatment with B lactis 420 significantly reduced fat mass in both of these groups, reflected as reduced weight gain and improved glucose tolerance.

The authors conclude that "B lactis 420 reduces fat mass and glucose intolerance in both obese and diabetic mice. Reduced intestinal mucosal adherence and plasma lipopolysaccharide suggest a mechanism related to reduced translocation of gut microbes."

Journal Reference:

"Potential probiotic Bifidobacterium animals ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice," Stenmen LK, Waget A, et al, Benef Microbes, 2014 Dec 1; 5(4):437-45. (Address: DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, 02460 Kantvik, Finland).